Nemo-like kinase (NLK) plays a role in cell fate determination and is required for differentiation of bone marrow stromal cells. It acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. It may suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. (referenced from swissprot)
Human,Mouse(predicted: Rat,Chicken,Pig,Cow,Rabbit,Sheep)
WB,IHC-P,IHC-F
Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.